Nature helps
Last resort for non-healing chronic wounds

The Problem

Chronic wounds have a poor prognosis. It is commonly defined as “a wound that does not heal in an orderly set of stages and in a predictable amount of time the way most wounds do; wounds that do not heal within three months are often considered chronic”.

Chronic wounds, such a leg and foot ulcers that occur in patients with diabetes mellitus and poor venous perfusion, which have been open for a long period of time frequently become infected by bacteria (e.g. Staphylococcus aureus).

The colonization of wounds (ulcers) with bacteria increasingly resistant to antibiotics often lead to complications, and results in inflammation that can hinder healing. Therapy very often ends in amputation of toes, feet or other limbs.

Some hospitals use living maggots to remove bacterial biomass as well as necrotic and fibrinous layers (debridement) from wounds. However, living sterile maggots cannot be stored, are difficult to handle logistically, and the sensation of crawling maggots on already painful wounds is perceived disagreeably by patients.

The Product

Larveel™ is a sterile powder made from 100% larvae of Lucilia sericata, reared by pharmacists under highest possible standards. The larvae are extracted and processed by unique patented procedures. Larveel powder is 100% sterile and stable for a long shelf-life.

Larveel™ was developed by scientists from the University of Duesseldorf and has been tested and applied in German hospitals with great success on ulcers of various origin, including diabetes, chronic venous insufficiency, peripheral arterial occlusive disease and chronic vein inflammation.

The Effect

Even though Larveel™ has no antibiotic properties it has a special effect on bacterial biofilms, making it easy to remove them. A few minutes after application Larveel™ forms an elastic film on the wound supporting the binding of bacteria and dead tissue to the wound dressing. During regular dressing changes these are simply removed from the wound. There are no known side-effects since Larveel™ has no antibiotic, no toxic nor pharmaceutical effects. Larveel™ promotes healing strictly by mechanical effects.

How to use

Larveel™ is applied as an in-house product under clinical surveillance. Larveel™ is only provided to clinics or physicians. It is important that the treating physician is first checking the wound status. If you are interested in detailed information or in purchasing Larveel™ send an e-mail to GIC medical service.

One vial of Larveel™ is good for wounds up to 20cm² wound. It is for external use only.

Application

  1. Add 2 ml of sterile isotonic saline solution into the vial of Larveel™ powder.
  2. Shake the Larveel™ vial gently until the powder is dissolved.
  3. With the use of a plastic pipette, take the fluid content from the vial and drop it onto the wound.
  4. Allow the fluid to air dry about 5 minutes until a type of film or gel has been formed on the wound surface, and then cover the wound with a paraffin gauze dressing to keep it moist. Secure it with an air permeable bandage.
  5. Dressing changes are recommended every 2-3 days.

References

Clinical Trial in Germany – PDF download

“Mehlhorn H, Gestmann F (2011) Extracts from Fly Maggots and Fly Pupae as a “Wound Healer”. In: Mehlhorn H (ed) Nature Helps: How Plants and Other Organisms Contribute to Solve Health Problems. Springer Berlin Heidelberg, Berlin, Heidelberg, p 325-348

Amal A., Diabetic Foot

Before (Oct. 12, 2015)
After (Nov. 30, 2015)

"I am astonished and deliriously happy. I think I can play soccer again."

Amal A.

Alsir E., Diabetic Foot

Before (Oct. 12, 2015)
After (Nov. 30, 2015)

"I am able to walk again without any pain. A million thanks to the German scientists."

Alsir E.